Morphological features of the respiratory part in guinea pigs lung in dynamics of experimental allergic inflammatory process

The main function of the components respiratory tract is gas exchange while maintaining homeostasis in lung, given pathogenic and non-pathogenic elements environment contained inhaled air. Morphological changes part lung human animals adaptive nature under influence various factors on body today remain insufficiently studied. aim study was to investigate morphological guinea pigs dynamics experimental ovalbumin-induced allergic inflammation. We used histological electron microscopic methods lungs 48 male inflammation, simulated by subcutaneous sensitization subsequent intranasal inhalation with ovalbumin. were determined early late phases inflammatory process at optical submicroscopic levels. phase (23rd 30th days experiment) characterized a predominance alterative destructive changes, consisted desquamation alveolar epithelium violation blood-gas barrier hemomicrocirculatory bed. Type II cells had lesions varying severity form absence lamellar bodies or disturbances formation their contents, vacuolization cytoplasm, mitochondrial damage. In development (36th 44th dominated restorative changes. addition, we observed dilation alveoli thinning interalveolar septa, which consequence cascade reactions local neuroendocrine immune systems as result allergen action. Thus, accompanied structural functional stages depending duration experiment.